Fitrianingsih Fitrianingsih


The aim of this study was proving the ability of VCO in increasing eNOS levels in Wistar rats fed HFD. This study used 25 male wistar rats were divided negative control is receiving with a normal diet, positive control receiving HFD, three treatment groups receiving a combination of HFD with VCO in dose of 1ml, 1,2 ml or 2 ml/day in period of 60 days. The blood taken from the eyes of rats and after end of this eNOS measurement done by using ELISA. The mean levels of eNOS group negative control, positive control, treatment 1,2, and 3 respectively are (1.95 ; 1.39 ; 1.47 ; 2.11 ; 2.55). The mean levels is higher than the group positive control but based on the results of One-Way ANOVA test showed that there were no significant differences in the mean levels of eNOS among all group treatment groups (p=0.305). VCO was not significantly increasing eNOS levels in HFD Wistar rats.


VCO, High Fat Diet, eNOS levels.

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A.G., Gopala Krishna, Gaurav Raj, Ajit Singh Bhatnagar, Prasanth Kumar P.K., and Preeti Chandrashekar. Coconut Oil: Chemistry, Production and it’s Applications-A Review. Indian Coconut Journal. Department of Lipid Science and Traditional Foods, Central Food Technological Research Institute.2010.

Al Arif. Minyak Kelapa Murni. (On line).2013. 26 Mei 2018)

Amelia, Rinita, Fadil Oenzil, Eliza Nasrul. Pengaruh Diet Tinggi Asam Lemak Terhadap Fungsi Endotel Pembuluh Darah Tikus Jantan Strain Wistar (Tesis). Universitas Andalas Padang.2011.

Anonim. Manfaat Virgin Coconut Oil.Online).2014. (diunduh 22 Juni 2014).

Enig MG. Coconut:in Support of good health in the 21 Century. (Online). 2001.Http// [accessed on 22 June 2014].

Fatmawati, Heni dkk. Pengaruh Likopen terhadap Penurunan Aktivitas Nuclear Factor Kappa Beta (NF-kB) dan Ekspresi Intracelular Cell Adhesion Molecule-1 (ICAM-1) pada Kultur HUVECs yang Dipapar Leptin. Jurnal Ilmu Dasar. 2010; 2 : 143-150.

Fotis, L., Georgios Agrogiannis and Ioannis S Vlachos. Intercellular Adhesion Molecule (ICAM)-1 and Vascular Cell Adhesion Molecule (VCAM)-1 at the Early Stages of Atherosclerosis in a Rat Model. In vivo 26. 2012 : 243-250.

Harini, Marti and Okid Parama Astirin. Blood Cholesterol Levels of Hypercholesterolemic Rats (Rattus norvegicus) After VCO Treatment. Bioscience.2009;2:53-58. oxide, Diunduh 24 Oktober 2013. oxide, Diunduh 24 Oktober 2013.

Institute of Medicine. Promoting Cardiovascular Health in the Developing World : A critical Challenge to Achieve Global Health. Washington, DC: The National Academies Press. 2010.

Köln, 2005. vorgelegt von-Norbert Gerdes-aus Altenberge (Thesis).

Marten, B., Maria P., Jurgen S.Medium–Chain Triglycerides. International Dairy Journal. 2006;16 :1374–1382.

N.Das, Undurti. Molecular Basic of Health and Disease. School of Biotechnology Jawaharlal Nehru Technological University, India. Springer London New York. 2011.

Nevin, K.G. dan T.Rajamohan, 2004. Beneficial Effect of VCO on Lipid Parameters and In Vitro LDL Oxidation. Clinical Biochemistry 830-835. Published by Elsevier Ltd.

Salimi S, Firoozrai M, Mourmohammadi I,Shabani M, Mohebbi A. Endothelial nitric oxide synthase gene intron4 VNTR polymorphisms in patients with coronary artery disease in Iran. Indian J Med Res.2006;124:683-8.

Tsalissavrina, Iva, 2006. Pengaruh Pemberian Diet Tinggi Karbohidrat dibandingkan Diet Tinggi Lemak Terhadap Kadar Trigliserida dan HDL Darah Pada Rattus norvegicus galur Wistar. Jurnal Kedokteran Brawijaya, vol XII no.2.

Yang, Zhihong and Xiu-Fen Ming. Recent Advances in Endhotelial Dysfunction in Aterosklerosis. Clinical Medicine & Research. 2006;1:53-65.

Yully Endang Hernani. Adinopektin Meregulasi Turun Ekspresi iNOS Pada Kultur HUVEC’s yang dipapar Lipopolisaccharide (LPS).Jurnal Kedokteran Brawijaya.2008.



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