An  Overview of Antibiotic Utilization in Typhoid Fever Inpatients at dr. Abdul Aziz Regional General Hospital, Singkawang: indonesia

Kathina Deswi Aqsa; Salsabela; Kharina Nisya

doi:10.31941/benzena.v5i01.7827

Authors

Kathina Deswi Aqsa Universitas Tanjungpura
Salsabela
Kharina Nisya

DOI:

https://doi.org/10.31941/benzena.v5i01.7827

Keywords:

Antibiotics, Typhoid Fever, Efficacy, Salmonella Typhi

Abstract

Background: Typhoid fever remains a major health concern in Indonesia, with a substantial incidence rate and risk of mortality. Rational antibiotic selection is critical to maximize recovery and mitigate resistance.

Objective: This study aims to determine the effectiveness of antibiotic use in typhoid fever patients at the Inpatient Ward of Dr. Abdul Aziz Singkawang General Hospital during the 2022 period.

Method: This study employed a non-experimental observational design with retrospective data collection from medical records the inclusion criteria of adult patients ³ 18 years , patients diagnosed with typhoid fever and hospitalized at Dr. Abdul Aziz Singkawang Regional General Hospital during the 2022 period, patients with a body temperature >37.5°C & patients receiving antibiotic therapy. Data were analyzed descriptively and analytically using Microsoft Excel 2019. The sampling technique used was purposive sampling with the Slovin formula, yielding a sample size of 104 out of 140 patients

Results: The results showed that typhoid fever was most commonly diagnosed in women (52%), with the majority of patients aged 18–45 years (44.2%). The most frequently used antibiotic was IV Ceftriaxone in 61 patients (58.65%), followed by PO Ciprofloxacin in 16 patients (13.38%), and the least common was Cefixime PO+ PO Ciprofloxacin in 1 patient.

Conclusion: Based on the study results, it can be concluded that the most commonly used antibiotic for typhoid fever patients at Dr. Abdul Aziz Singkawang General Hospital was IV Ceftriaxone, administered to 61 patients (58.65%).

Downloads

Download data is not yet available.

References

Adiputra et al. (2017) ‘Karakteristik Klinis Pasien Demam Tifoid di RSUP Sanglah Periode Waktu Juli 2013 - Juli 2014’, E- jurnal medika udayana, 6(11), pp. 98–102.

Alkhodiyah, U. et al. (2020) ‘Evaluasi Kuantitas Penggunaan Antibiotik Pasien Demam Tifoid di Instalasi Rawat Inap RSUD Kraton Pekalongan Tahun 2019’, Medical Sains : Jurnal Ilmiah Kefarmasian, 5(1), pp. 31–42. Available at: https://doi.org/10.37874/ms.v5i1.157.

Dyson, Z.A. et al. (2019) ‘Antibiotic resistance and typhoid’, Clinical Infectious Diseases, 68(Suppl 2), pp. S165–S170. Available at: https://doi.org/10.1093/cid/ciy1111.

Feny Oktaviana, P.N. (2021) ‘Efektivitas Terapi Antibiotika Demam Tifoid Pada Pediatrik Di Rumah Sakit X Kota Kediri’, Syifa Sciences and Clinical Research, 3(2), pp. 63–70.

Fithria, R.F., Damayanti, K. and Fauziah, R.P. (2015) ‘Perbedaan Efektivitas Antibiotik pada Terapi Demam Tifoid di Puskesmas Bancak Kabupaten Semarang Tahun 2014’, Prosiding Seminar Nasional Peluang Herbal sebagai Alternatif Medicine, pp. 1–6.

Hazimah, K.W., Priastomo, M. and Rusli, R. (2019) ‘Analisis Efektivitas Biaya Penggunaan Antibiotik pada Pasien Demam Tifoid di RS SMC Periode 2017’, Jurnal Sains dan Kesehatan, 2(2), pp. 107–114. Available at: https://doi.org/10.25026/jsk.v2i2.126.

HELMY, A. (2020) ‘GAMBARAN PENDERITA DEMAM TIFOID DI BEBERAPA LOKASI DI WILAYAH INDONESIA PERIODE TAHUN 2010 SAMPAI DENGAN TAHUN 2020’, SKRIPSI, pp. 2–73.

ISLAMI, L.D.N. (2021) ‘EFEKTIVITAS PENGGUNAAN OBAT ANTIBIOTIK UNTUK TERAPI DEMAM TYPHOID DI INSTALASI RAWAT INAP RSUD dr. SOEROTO NGAWI’, Industry and Higher Education, 3(1), pp. 1689–1699.

Kuehn, R. et al. (2022) ‘Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins’, Cochrane Database of Systematic Reviews, 2022(11). Available at: https://doi.org/10.1002/14651858.CD010452.pub2.

Melarosa, P.R., Ernawati, D.K. and Mahendra, A.N. (2019) ‘Pola Penggunaan Antibiotika Pada Pasien Dewasa Dengan Demam Tifoid Di Rsup Sanglah Denpasar Tahun 2016-2017’, E-Jurnal Medika Udayana, 8(1), p. 12. Available at: https://doi.org/10.24922/eum.v8i1.45224.

Milligan, R. et al. (2018) ‘Vaccines for preventing typhoid fever’, Cochrane Database of Systematic Reviews, 2018(5). Available at: https://doi.org/10.1002/14651858.CD001261.pub4.

NICD (2022) ‘Enteric fever ( typhoid and paratyphoid fever ): Recommendations for diagnosis , management and public health response’, Enteric Fever Guideline, (June), pp. 1–25.

Oktavia, D.L.I. (2020) ‘The Evaluation Of Antibiotic Administration To Tifoid Fever Patients At Azra Hospital Inpatient Installation In Bogor City’, Fitofarmaka Jurnal Ilmiah Farmasi, 10(1), pp. 1–64.

Pratiwi, A. and Mayasari, D. (2009) ‘Hubungan Respon Imun Dan Stres Dengan Tingkat Kekambuhan Demam Tifoid Pada Masyarakat Di Wilayah Puskesmas Colomadu Karanganyar’, Berita Ilmu Keperawatan, 2(1), pp. 115–120.

Pratiwi, R.I. and Anggy Rima Putri (2022) ‘Perbandingan Efektivitas Ceftriaxone Dan Cefotaxime Pada Pasien Anak Demam Tifoid Di Rumah Sakit Mitra Siaga’, Jurnal Ilmiah Manuntung, 8(1), pp. 8–13. Available at: https://doi.org/10.51352/jim.v8i1.461.

Prawesti, M., Mursiany, A. and Walid, M. (2022) ‘Penggunaan Antibiotika Kombinasi Cefotaxim-Thiamfenicol Pada Pasien Pediatri Penderita Demam Tifoid Di Rawat Inap Rsu Budi Rahayu Tahun 2016’, BENZENA Pharmaceutical Scientific Journal, 1(01), pp. 64–76. Available at: https://doi.org/10.31941/benzena.v1i01.2108.

Rahmawati, A. et al. (2019) ‘Efektifitas Antibiotik Pasien Demam Tifoid Rsup Dr. M. Djamil Padang’, 2(2), pp. 13–28. Ramaningrum, G., Anggraheny, H.D. and Putri, T.P. (2017) ‘Faktor-faktor yang mempengaruhi kejadian demam tifoid pada anak di RSUD Tugurejo Semarang’, Fakultas Kedokteran Universitas Muhammadiyah Semarang, 10(2), pp. 1–8.

Sagar A. Chandankhede, Janhavi Y. Bure, F.A.S. and S.W.G. (2022) ‘A REVIEW ON TYPHOID INFECTIOUS BACTERIAL DISEASE’, World Journal of Pharmaceutical Research, 11(17), pp. 669–680. Available at: https://doi.org/10.20959/wjpr202217-26575. Sari, G.P., Artini, K.S. and Wardani, T.S. (2023) ‘EFEKTIVITAS ANTIBIOTIK PASIEN DEMAM TIFOID RAWAT INAP DI RSAU dr. SISWANTO LANUD ADI SOEMARMO TAHUN 2022’, Parapemikir : Jurnal Ilmiah Farmasi, 12(3), p. 328. Available at: https://doi.org/10.30591/pjif.v12i3.5379.

Susatyo, Jeffry, A. (2016) ‘the Usage Comparison of Ceftriaxone and Chloramphenicol for Typhoid Fever Treatment: an Evidence Based Case Report’, Tropical and Infectious Disease, 6(3), pp. 74–77.

Umair, M. and Siddiqui, S.A. (2020) ‘Antibiotic Susceptibility Patterns of Salmonella Typhi and Salmonella Paratyphi in a Tertiary Care Hospital in Islamabad’, 12(9). Available at: https://doi.org/10.7759/cureus.10228.

Yan Marvellini, R. and Tesalonika Bunga Ria Sagala, F. (2020) ‘Gambaran Efektivitas Seftriakson Dan Sefotaksim Pada Pasien Demam Tifoid Usia 5 – 19 Tahun Di Rsud Bekasi Periode Januari 2019 -Desember 2019’, Jurnal Kedokteran Universitas Palangka Raya, 8(2), pp. 1020–1024. Available at: https://doi.org/10.37304/jkupr.v8i2.2036.