The Profile of Type 2 DM Patients with Insulin Resistance at Citra Husada Hospital

Authors

  • Rizki Eko Prasetyo Diponegoro University

DOI:

https://doi.org/10.31941/pmjk.v12i2.2535

Abstract

Type 2 DM is a complex chronic multifactorial disease involving many organs. Insulin resistance in type 2 DM patients that occurs due to insulin deficiency or insulin defects can also occur due to metabolic syndrome. This study aims to determine the profile of type 2 DM patients with insulin resistance based on the characteristics of HbA1c levels, leukocyte levels, and hypertension status at Citra Husada Jember Hospital in 2022. This study used a descriptive method with a case series design. The population study consisted of 40 type 2 DM patients who underwent outpatient care in May 2022 using a total sampling technique. The results of the study showed the characteristics of type 2 DM patients with HbA1c levels > 6.5 (25%), 30% leukocytosis, and 45% hypertension. This condition continues even though blood glucose is controlled due to the phenomenon of metabolic memory. The addition of natural bioactive compounds in type 2 DM patients receiving metformin therapy can overcome metabolic memory.

Keywords: Type 2 DM, metabolic memory, HbA1c, leukocyte, hypertension

References

Berezin, A. 2016. Metabolic Memory Phenomenon In Diabetes Mellitus: Achieving And Perspectives, Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 10(2), hal. S176–S183. Tersedia pada: https://doi.org/10.1016/j.dsx.2016.03.016.

Cataloguing, W.L. 2016. Global Report on Diabetes, ISBN, 978, hal. 6–86. Tersedia pada: https://apps.who.int/iris/handle/10665/204871.

Ferreira, J.P. et al. 2020. Metabolic Syndrome In Patients With Type 2 Diabetes And Atherosclerotic Cardiovascular Disease: A Post Hoc Analyses Of The Empa-Reg Outcome Trial, Cardiovascular Diabetology, 19(1), hal. 1–9. Tersedia pada: https://doi.org/10.1186/s12933-020-01174-6.

Gerich, J.E. 2003. Contributions Of Insulin-Resistance And Insulin-Secretory Defects To The Pathogenesis Of Type 2 Diabetes Mellitus, Mayo Clinic Proceedings, 78(4), hal. 447–456. Tersedia pada: https://doi.org/10.4065/78.4.447.

Gonie, B.M.T., Wantania, F.E.N. dan Umboh, O.R.H. 2017. Gambaran Kadar Asam Urat pada Pasien Infark Miokard Akut di RSUP Prof. Dr. R. D. Kandou Manado Periode September 2016 – Agustus 2017, e-CliniC, 5(2). Tersedia pada: https://doi.org/10.35790/ecl.5.2.2017.18573.

Grundy, S.M. 2016. Metabolic Syndrome Update, Trends In Cardiovascular Medicine, 26(4), hal. 364–373. Tersedia pada: https://doi.org/10.1016/j.tcm.2015.10.004.

Insuela, D. et al. 2020. Neutrophil Function Impairment Is a Host Susceptibility Factor to Bacterial Infection in Diabetes, Cells of the Immune System, hal. 1–22. Tersedia pada: https://doi.org/10.5772/intechopen.86600.

Kemenkes. 2020. Infodatin tetap produktif, cegah, dan atasi Diabetes Melitus 2020, Pusat Data dan Informasi Kementrian Kesehatan RI, hal. 1–10. Tersedia pada: https://pusdatin.kemkes.go.id/resources/download/pusdatin/infodatin/Infodatin-2020-Diabetes-Melitus.pdf.

Kementrian Kesehatan Republik Indonesia/Kemenkes RI. 2018. Laporan_Nasional_RKD2018_FINAL.pdf, Badan Penelitian dan Pengembangan Kesehatan, hal. 674. Tersedia pada: http://labdata.litbang.kemkes.go.id/images/download/laporan/RKD/2018/Laporan_Nasional_RKD2018_FINAL.pdf.

Leukosit, P.J. et al. 2018. Perbedaan Jumlah Leukosit, Neutrofil Dan Limfosit Absolut Pada Penderita Dm Tipe 2 Terkontrol Dan Tidak Terkontrol, 7(2), hal. 854–862.

Ludirdja, J.. et al. 2010. Rerata Durasi Penderita Diabetes Melitus Terkena Nefropati Diabetik Sejak Terdiagnosis Diabetes Melitus Pada Pasien Di Poliklinik Geriatri Rsup Sanglah, Jurnal IPTEKMA, 2(1), hal. 1–4.

Ormazabal, V. et al. 2018. Association Between Insulin Resistance And The Development Of Cardiovascular Disease, Cardiovascular Diabetology, 17(1), hal. 1–14. Tersedia pada: https://doi.org/10.1186/s12933-018-0762-4.

Paputungan, S.R. dan Sanusi, H. 2014. Peranan Pemeriksaan Hemoglobin A1c pada Pengelolaan Diabetes Melitus, Cdkjournal, 24(3), hal. 90–94.

Reed, J., Bain, S. dan Kanamarlapudi, V. 2021. A Review Of Current Trends With Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments And Future Perspectives, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, hal. 3567–3602. Tersedia pada: https://doi.org/10.2147/DMSO.S319895

Sari, G.P., Samekto, M. dan Adi, M.S. 2017. Faktor-Faktor Yang Berpengaruh Terhadap Terjadinya Hipertensi Pada Penderita Diabetes Melitus Tipe Ii (Studi Di Wilayah Puskesmas Kabupaten Pati), Jurnal Litbang: Media Informasi Penelitian, Pengembangan dan IPTEK, 13(1), hal. 47–59. Tersedia pada: https://doi.org/10.33658/jl.v13i1.92.

Sherwani, S.I. et al. 2016. Significance Of Hba1c Test In Diagnosis And Prognosis Of Diabetic Patients, Biomarker Insights, 11, hal. 95–104. Tersedia pada: https://doi.org/10.4137/Bmi.s38440.

Sugiharto, A. et al. 2007. Faktor-Faktor Risiko Hipertensi Grade II Pada Masyarakat ( Studi Kasus di Kabupaten Karanganyar ) Risk Factors of Grade II Hypertension in Community (Case Study at Karanganyar District) PDF created with pdfFactory Pro trial version www.pdffactory.com Fa,” Ratio, 26. Tersedia pada: http://eprints.undip.ac.id/5265/.

Utomo, A.Y.S., Julianti, H.P. dan Pranomo, D. 2011. Hubungan Antara 4 Pilar Pengelolahan Diabetes Mellitus Dengan Keberhasilan Pengelolhan Diabetes Mellitus Tipe 2, 1(2). Tersedia pada: http://eprints.undip.ac.id/32797/1/Acmad_Yoga.pdf.

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Published

2023-01-04

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Vol. 12 No. 2 (2022): PENA MEDIKA JURNAL KESEHATAN

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