Analysis Potential Drug’s Interaction In Prescription Compouded At Arbai Pharmacy From January To March 2024

Penulis

  • Indah Sri Hartini Institut Ilmu Kesehatan Bhakti Wiyata Kediri
  • Fenita Shoviantari Institut Ilmu Kesehatan Bhakti Wiyata Kediri
  • Wika Admaja Institut Ilmu Kesehatan Bhakti Wiyata Kediri
  • Hartati Tuna Institut Ilmu Kesehatan Bhakti Wiyata Kediri
  • Yogi Bhakti Marhenta Institut Ilmu Kesehatan Bhakti Wiyata Kediri

Abstrak

Prescriptions compounded are prescriptions that have the potential for drug’s interactions. Drug-drug interactions can occur pharmaceutically, pharmacokinetically, and pharmacodynamically. These interactions can cause a decrease in effectiveness, an increase in drug toxicity, resulting in the failure to achieve the expected therapeutic goals. The potential for drug-drug interactions can occur in both compounded and non-compounded prescriptions. Compounded prescriptions are often given to children to adjust the dosage as needed. This study aims to determine the potential for drug-drug interactions in compounded prescriptions at the Arbai Bandar Lor Pharmacy. This study is descriptive and non-experimental. Data collection was conducted retrospectively on compounded prescriptions from January to March 2024 that met the inclusion and exclusion criteria. Determining drug-drug interactions using the Drug Interaction Checker 2024 application Results and conclusions: Pharmaceutically, there were 2 unstable prescriptions (1.90%) and 103 compatible prescriptions (98.10%). The results of the analysis of potential drug-drug interactions  were found in 21 prescriptions (20%). The mechanism of interaction was pharmacokinetic in 7 (46.67%) combinations and pharmacodynamic in 8 (53.33%) combinations, with a minor severity level in 4 (26.67%) cases and a moderate severity level in 11 (74.33%) cases, based on the Medscape Drug Interaction Checker reference.

Referensi

Amarullah, A., Nuur, R., Puteri, R., Charles, I., Klau, S., Anwari, F., & Aristia, B. F. (2025). Analisis Potensi Interaksi Obat pada Pasien Layanan Apotek. Jurnal Farmasi Ma Chung: Sains Teknologi Dan Klinis Komunitas p–ISSN, 3(1), 30–33. https://doi.org/10.33479/jfmc.v3i1.59

Brayfield, A., Cadart, C., & Baxter, I. A. (2014). Martindale : The Complete Drug Reference (A. Brayfield & C. Cadart (eds.); 38th ed.). Pharmaceutical Press.

Febrianti, Y., Ardiningtyas, B., & Asadina, E. (2018). Kajian Administratif , Farmasetis , dan Klinis Resep. Jurnal Pharmascience, 05(02), 163–172.

Kemenkes RI. (2020). Faarmakope Indonesia VI (KemenKes (ed.)). Kemenkes Ri.

Lund, W. The Pharmaceutical Codex (12th Ed.). London: The Pharmaceutical Press. 2009

Nego, M. A., & Gayatri, A. (2023). Potensi Interaksi Obat Tersering pada Pasien Sakit Kritis. Journal of The Indonesian Medical Association, 73(September 2023), 206–212.

Permenkes. (2016). Peraturan Menteri Kesehatan Republik Indonesia Nomor 73 Tahun 2016 Tentang Standar Pelayanan Kefarmasian Di Apotek.

Permenkes. (2017). Peraturan Menteri Kesehatan Republik Indonesia Nomor 9 Tahun 2017 Tentang Apotek (9).

Preston, C. L. (2015). Stockley’s Drug Interactions Pocket Companion. Pharmaceutical Press. https://books.google.co.id/books?id=bR64wAEACAAJ

Rochjana, A. U. H., Jufri, M., Andrajati, R., & Sartika, R. A. D. (2019). Masalah Farmasetika dan Interaksi Obat pada Resep Racikan Pasien Pediatri : Studi Retrospektif pada Salah Satu Rumah Sakit di Kabupaten Bogor Pharmaceutics and Drug Interaction Problems in Pediatric Patients Prescription : Retrospective Study at a Hospita. Jurnal Farmasi Klinik Indonesia, 8(1), 42–48. https://doi.org/10.15416/ijcp.2019.8.1.42

Syamsuddin, P., & Purnamasari, V. (2024). As-Syifaa Jurnal Farmasi. As-Syifaa Jurnal Farmasi, 16(1), 52–62.

Zempleni, J., Rucker, R. B., McCormick, D. B., & Suttie, J. W. (2007). Handbook of VITAMINS (4th ed.). CRC Press.

Unduhan

Diterbitkan

2025-12-31

Terbitan

Vol 15 No 2 (2025): PENA MEDIKA: JURNAL KESEHATAN

Bagian

Artikel

Lisensi

Hak Cipta (c) 2025 Indah Sri Hartini, Wika Admaja, Fenita Shoviantari, Hartati Tuna, Yogi Bhakti Marhenta

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